MOLECULAR DYNAMICS SIMULATIONS OF INSULIN: ELUCIDATING THE CONFORMATIONAL CHANGES THAT ENABLE ITS BINDING.

A sequence of complex conformational changes is required for insulin to bind to the insulin receptor.Recent experimental evidence points to the B chain C-terminal (BC-CT) as the location of these changes in insulin.Here, we present molecular dynamics simulations of insulin that reveal new insights into the structural changes occurring in the BC-CT.

This paper empirically evaluates the crucial dimensions of logistics skill requirements and their discrepancy for logistics operation first line employees from industrial and academic perspectives.Factor analysis was employed to identify crucial business and logistics skill factors in Taiwan.ANOVA was then conducted to analyse the difference percep